Valerian Root

Valerian is an herb native to Asia and Europe. Its root has been used to promote relaxation and sleep.

Valerian contains a number of compounds that may help promote calmness by reducing GABA breakdown, improving stress response and maintaining adequate levels of mood-stabilizing brain chemicals.⁽⁹⁾

Melatonin

Melatonin is a hormone produced by the pineal gland in your brain responsible for regulating your body’s sleep cycle. 

In addition to improving sleep, melatonin is also involved in managing immune function, blood pressure and cortisol levels.⁽¹⁰⁾

GABA

GABA is a naturally occurring amino acid that works as a neurotransmitter in your brain. Neurotransmitters function as chemical messengers.

GABA’s natural calming effect on the brain has led to countless claims about the use of GABA supplements to reduce stress. Too much stress is linked to poor sleep, a weaker immune system, and a higher risk of depression.⁽¹²⁾

5-HTP

5-HTP is an amino acid that your body naturally produces. Your body uses it to produce serotonin, a chemical messenger that sends signals between your nerve cells.

Low serotonin levels are associated with depression, anxiety, sleep disorders, weight gain and other health problems.

5-HTP may promote sleep by increasing melatonin production, an important sleep-regulating hormone. 5-HTP may help you have fewer migraines by increasing your serotonin levels.⁽¹³⁾

Magnesium

Magnesium is a mineral that supports hundreds of chemical reactions in your body.

Magnesium can help you sleep better, have more energy, relax muscles, reduce inflammation, and lower blood pressure levels.⁽¹⁴⁾

Tryptophan

Tryptophan is an amino acid that can be converted into several important molecules, including serotonin and melatonin. Tryptophan and the molecules it produces influence many functions in the body, including sleep, mood and behavior.

Research has shown that low levels of tryptophan may contribute to mood disorders, including depression and anxiety.⁽¹⁵⁾